Abstract
By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).
MeSH terms
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Animals
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Chromans / chemistry*
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Chromans / metabolism
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Chromans / pharmacology*
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Chromones / pharmacology
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Guinea Pigs
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Humans
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Indoles
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Leukotriene Antagonists / chemistry*
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Leukotriene Antagonists / metabolism
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Leukotriene Antagonists / pharmacology*
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Leukotriene D4 / antagonists & inhibitors*
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Leukotriene D4 / metabolism
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Phenylcarbamates
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Protein Binding
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Sulfonamides
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Tosyl Compounds / pharmacology
Substances
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Chromans
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Chromones
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Indoles
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Leukotriene Antagonists
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Phenylcarbamates
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Sulfonamides
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Tosyl Compounds
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Leukotriene D4
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2,2,5,7,8-pentamethyl-1-hydroxychroman
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pranlukast
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zafirlukast